Apart from potentially preventing a particular disease, vaccines may cause persistent nonspecific effects that can affect a person’s lifetime survival.
In a review published on Dec. 26, 2023, in Vaccine, researchers found that non-live vaccines such as influenza, COVID-19, hepatitis B, and diphtheria-tetanus-pertussis (DTaP) tend to cause adverse nonspecific effects (NSE), increasing a person’s risks of all-cause mortality and infections from other diseases.
A live vaccine contains a weakened form of the pathogen, which is less virulent but capable of replicating in the body, thus mimicking the actual disease progression. Non-live vaccines use inactivated viruses, fragments, or genes of the pathogen to trigger an immune response without pathogen replication.
Live vaccines elicit a much stronger immune defense, typically requiring only one shot, while non-live vaccines result in a weaker response, often necessitating multiple shots.
So far, research has identified several non-live vaccines that cause adverse NSEs, namely DTaP and Tdap, influenza H1N1, malaria, hepatitis B, inactivated polio, and COVID-19 mRNA vaccines.
The Vaccine study singled out DTaP, influenza, malaria, hepatitis B, and COVID-19 mRNA vaccines.
